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Epigenetics
101
- Dr. Bruce
Lipton,
PhD
"TAD" IS
TRANSIENT
ACANTHOLYTIC
DFERMATOSIS
SYNONYM TO
GROVER'S DISEASE
May 15, 2019
There are synonyms for a rare skin disease "GROVER'S DISEASE." Synonyms are words that are similar, or have a related meaning, to another word.[1] Wikipedia explains, "A synonym is a word or phrase that means exactly or nearly the same as another lexeme (word or phrase) in the same language."[2]
The terms like "TAD" and "Transient Acantholytic Dermatosis" and "GROVER'S DISEASE mean exactly or nearly the same. They are synonyms.
Derm101 is a comprehensive digital resource for healthcare professionals at all levels of training and practice[3] explains about "Grover’s Disease / Transient Acantholytic Dermatosis" in its website. [4]
The website for "DERM101.COM" writes, "Grover’s disease, also known as transient acantholytic dermatosis (TAD), is a common pruritic condition that typically affects adult individuals and classically presents on the trunk and proximal extremities." [4]
The content of this information in "DERM101.COM" includes the following: " may be more common in Caucasian individuals, especially in the fifth to seventh decades of life.The characteristic lesion is a crusted erythematous papule, pustule, or papulovesicle." [4]
RALPH WIER GROVER
Dermatologist
Birthday: 12/26/1920
Death: May 25, 2008
According to the website "www.mylife.com":
"Ralph Grover has passed away, we regret to report; date of death was 05/25/2008, Ralph was 87 years old at the time. Ralph's Reputation Score was 3.75. Previously, Ralph Grover had lived in Greenport, NY. In the past, Ralph has also been known as Grover R Wier, Ralph Wier Grover, Ralph W Grover and Ralph W Groven. "
Source:
On May 25, 2008:
Ralph Grover has passed away
Ralph Wier Grover: Birthday: 12/26/1920; Death: May 25, 2008 (Ralph was 87 years old at the time).
Ralph Grover had lived in Greenport, NY. In the past, Ralph has also been known as Grover R Wier, Ralph Wier Grover, Ralph W Grover and Ralph W Groven.
Source:
On May 25, 2008:
Ralph Grover has passed away
In the journal of American Academy of Dermatology (JAAD), James M. Krivo, MD, A. Bernard Ackerman, MD and Marvin I. Lepaw, MD, Valley Stream, New York, and Dix Hills, New York published their memories in "In memoriam: Dr Ralph Wier Grover: Friend, teacher, and dermatologist". [8]
In this memoriam, James M. Krivo, MD writes, "I have had the privilege of being one of the people
who has learned something about medicine and dermatology from Dr Ralph Grover. Ralph passed way on May 25, 2008. He was a physician, a teacher, a researcher, a friend, a father, and a
husband." [8]
Author, Dr. Krivo adds, "His home office in Floral Park, NY was a place where residents, medical students, and interns in training would rotate to learn from a dedicated teacher, where he stored all the information needed the old-fashioned way, on little 436 cards filled with beautiful drawings, diagramming where and what lesions looked like." [8]
This dermatologist in this memoriam goes on to say, "Going to his office was as much like going to a relative’s home as a doctor’s office. Everyone knew about the pet ducks that he kept in his yard. And he spent time with his patients as much as they needed." [8]
The writer in JAAD's memoriam points out to Dr. Grover's wife and says, "His wife, Jean, was always
around to help in the office or in the clinic he voluntarily directed at Nassau County Medical
Center."
This dermatologist in Garden City, New York, Dr. James M. Krivo talks about Dr. Grover's preferred techniques and writes, "He had perfected techniques of cytology and Tzanck smears, and did such testing whenever there was a puzzling rash." [8]
He continues, " Using cytologic examinations when removing basal cell carcinomas, he was
able to do a virtual Mohs technique even before the Mohs technique was being used on a large scale." [8]
Dr. James Krivo of Garden City, New York addresses, "Doing Tzanck smears" by Dr. Grover and provides the following information: "It was in doing Tzanck smears that he discovered the disease that now carries his name, Grover’s disease. Whoever was lucky enough to be around him was brought to a higher level of understanding." [8]
He includes also the following information: "And wherever he went he brought his humor and love.
He will be missed and never forgotten, and all the people who learned from him will be carrying on his tradition of caring and joy." [8]
In memoriam in JAAD, A. Bernard Ackerman writes, "To have been a solo practitioner of dermatology
and to have identified a disease ‘‘missed’’ for centuries by ‘‘experts’’ in academe is no surprise to those who knew the brilliant turn of mind of Ralph."[8]
Dr. Ackerman adds, "He was an original in every respecteand a joy to work with. Not only did he have a marvelous, wry sense of humor, but he could be playfully puckish in selfdeprecation." [8]
The author also says, "As but one example, his middle name was ‘‘Wier,’’ about which he commented to me, ‘‘they left off the ‘d’!’’ It is regrettable that Ralph Wier Grover was not known ersonally to colleagues and trainees beyond Long Island. They would have reveled in his company and in his intellect, just as did I." [8]
Dr. Marvin I. Lepaw, in this JAAD's memoriam writes, "I have had the extreme good fortune to have
worked in Ralph W. Grover’s office from 1965 to 1970. He started the first dermatology clinic at
Meadowbrook Hospital (now known as Nassau University Medical Center) when I was an intern there."[8]
Author of this memoriam, Dr. Laepaw adds, "During that internship and into my residency in internal medicine, inpatients with unusual or interesting skin problems were presented to him
on a weekly basis at that clinic." [8]
He continues to say, "He was a fantastic dermatologic teacher, diagnostician, and histopathologist.
During the past 47 years he maintained a close relationship with many of us younger dermatologists
and we are grateful for his lifelong contributions and devotion to our field." [8]
Dr. Lepaw with sorrow and sadness notes this: "I will miss him as a teacher and a friend." [8]
NATIONAL ORGANIZATION FOR RARE DISEASE (NORD) has a website in the Internet which is "RAREDISEASE.ORG".NORD’s policy team works with policy makers on Capitol Hill, in the White House, in government agencies. [5]
The Website of "NORD" writes about GROVER'S DISEASE with the following words: "Grover's disease is a rare, transient skin disorder that consists of small, firm, raised red lesions, most often on the skin of the chest and back." [6]
The NORD's website adds, "Diagnosis of this disorder becomes apparent under microscopic examination when the loss of the "cement" that holds the skin cells together is observed." [6]
the website for the National Organization for Rare Disorders (NORD) goes on further to say, "Over time, as the skin loses the "cement", the cells separate (lysis). Small blisters containing a watery liquid are present. These blisters tend to group and have a swollen red border around them." [6]
This website also addresses that Grover's disease is mainly seen in males older than forty or fifty. Its cause is unknown but it is thought to be related to trauma to sun damaged skin.[6]
The website for "DERM101.COM" points out to the lesions in GROVER'S DISEASE and notes, "Lesions of transient acantholytic dermatosis (TAD) often are not “transient,” and may persist for years, especially in the inframammary regions." [4]
This website addresses the things like heat and sweating and explains, "Heat, sweating, and occlusion appear to be triggers, with patients presenting after trips to tropical or semitropical climates, with fever, and after hospitalization or bed rest." [4]
There are information in DERM101.COM about treatment and medications. It says, "Certain medications have been reported in association with Grover’s disease: anastrozole, vemurafenib, dabrafenib, cetuximab, mercury, D-penicillamine." [4]
On January 1, 2010, Shawn Bishop, Mayo Clinic - Senior Communications Specialist, in an article "Treatment for Grover’s Disease Geared Toward Relieving Itching and Rash" published in the website "newsnetwork.mayoclinic.org".[7]
The author, Bishop who is a communications specialist writes, "Grover's disease — also known as transient acantholytic dermatosis — is a condition where itchy red spots appear without warning, usually on a person's back or upper chest. The condition has no cure." [7]
Jul 1971, PubMed:
Transient
Acantholytic
Dermatosis:
Electron
Microscope Study
05/25/2008,
Ralph Grover
has passed away,
Ralph was
87 years old
we regret
to report
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